How The Metabolism Of Alcohol Causes More Harm Than Good
Folks, this is why we ought not to be binge drinking alcohol.
We love to unwind on weekends with a nice cocktail at a bar somewhere. There’s always some reason to be drinking, whether it be because we want to celebrate, or if we want to drown our sorrows, or if we want to relax.
But whether we’re partying or trying to drown our sorrows — whatever state of emotion we’re in, we do have to understand that drinking isn’t exactly the main problem — it’s what happens as the alcohol gets metabolised by the liver prior to excretion.
The biochemistry of alcohol metabolism
The cells in our liver take 2 steps to metabolise the alcohol (found as ethanol) into acetate (which is commonly known as vinegar).
1. Initially, the alcohol dehydrogenase (ADH) enzyme converts ethanol into acetaldehyde.
2. The acetaldehyde dehydrogenase (ALDH) enzyme then converts acetaldehyde into acetate.
Both these reactions are oxidation reactions, where electrons are removed from the ethanol (Step 1) and acetaldehyde (Step 2). These electrons are transferred to nicotinamide adenine dinucleotide (NAD+), which then reduces NAD+ down to its reduced state of NADH.
Unfortunately, the rate of Step 2 activity tends to be slower than the rate of Step 1, hence when one drinks alcohol in excessive amounts, their faces tend to go red, they get nauseous, and they get dizzy. Those are symptoms of acetaldehyde toxicity right there. Therefore, Asian flush is also a symptom of excess acetaldehyde in the blood.
Why do we call it Asian flush though? This article mentions that:
Due to genomic differences, 80 per cent of Asians have an overactive alcohol dehydrogenase. Hence, they break down alcohol into acetaldehyde very quickly — even up to 100 times quicker. Since alcohol is broken down faster, this is why you might experience little to no alcohol “buzz”.
On the other hand, most Asians have an inactive variant of the second before-mentioned liver enzyme ALDH2. This means that the by-product acetaldehyde takes a much longer to clear from their blood.
What happens when we have too much acetaldehyde in the blood?
Of course, acetaldehyde is a reactive aldehyde and contains those reactive carbonyl groups…
These reactive carbonyl groups can react with other biomolecules in our body, such as proteins. They can also react with cellular DNA to force mutations and potentially cause cancer, similar to the effects of charred foods:
It is important to note that we don’t get cancer from one night of binge drinking. We are at higher risks of developing it, however, if the drinking was sustained chronically over a long period of time.
This is essentially why alcoholics are at greater risk of developing liver cancer.
Their liver has to metabolise all the alcohol that they are consuming. If they drink themselves drunk on a regular basis, there will be constant periods of time when their blood acetaldehyde levels are higher than normal, which then has a higher propensity to cause greater amounts of damage to their liver cells.
A far greater amount of electron transfer reactions are occurring, with a higher risk of those transfers going wrong and causing oxidation-related damage to the liver. As more damage is sustained to the liver, the probability of developing liver cancer/health complications would then be much greater, no?
But guess where else we do get aldehydes in our diet from? All the dietary carbohydrates that we’re ingesting, of course:
(Because that’s good for business.)
Unless, of course…
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